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Currently, several types of wound dressings of varied architectures are available. All these structures are prefabricated and need the use of mechanical insertion for the removal from the site. Designs which can be controlled as per the requirements of the patients as well as easily removable, preferably by wetting or reducing the temperature at the application sites are unknown. We have synthesized a macromonomer using the polysaccharide chitosan which gels in situ by visible light and hence can be used for the closure of deep wounds easily. At the time of removal, the dried gel can be wiped off simply by wetting with cold water due to its thermal responsiveness. These gels may be used as wound dressings, drug delivery matrix, cell encapsulation, cell retrieval, and growth factor delivery in tissue engineering. This liquid formulation is unique as it gels in situ at the application site simply by visible light. This can be used for the complete packing of a deep wound without damaging the tissue. Hence, this is anticipated to have good market potential.


in situ gelling polysaccharide macromonomer drug delivery wound dressing toxicity

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Radhakumary, C., Krishna, A. S., & Sreenivasan, K. (2021). Chitosan Based Visible Light Induced In situ Gelling Hydrogel As Potential Wound Dressings. Trends in Biomaterials & Artificial Organs, 35(4), 342-346. Retrieved from