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Twenty clinically healthy adult New Zealand white rabbits of either sex were randomly divided into three groups (I, II and III). Group I and II consisted of eight animals each and in the control group (III) having four animals. Under ketamine (44mg/kg, IM) and xylazine (5 mg/kg, IM) anaesthesia a full thickness abdominal wall defect (2x3 cm) was created and   immediately repaired with 0.5% glutaraldehyde treated bovine diaphragm in groups I and II. In control group the defect was repaired by autograft. In group II ultrasound therapy was given at the repair site from day 3 postoperative at the rate of 0.5 watt/cm2 for 5 minutes for two weeks on alternate day. TThe grafts were very well taken up by host without any immune reaction. Ultrasound therapy reduced the adhesions in group II. Hexosamine level reduced in all the groups at day 21. Collagen, hydroxyproline and elastin increased at day 21. Changes in zinc and copper was statistically non significant. Rise in glucose and alkaline phosphatase were although significant but transient. Normal inflammatory cellular reaction was seen in all groups The healing was seen without any complication in all groups.


glutaraldehyde, bovine diaphragm, ultrasound therapy, rabbit

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Author Biography

Naveen Kumar, Division of Surgery, 1Division of Pathology, ICAR-Indian Veterinary Research Institute Izatnagar 243122, Uttar Pradesh, India

Principal Scientist, Division of Surgery, Indian Veterinary Research Institute, Izatnagar-243122, Bareilly (U.P.)

How to Cite
Baboo, K., Sharma, A. K., Kumar, N., Maiti, S. K., Singh, K., Gopinathan, A., & Sharma, A. K. (2021). Glutaraldehyde Crosslinked Bovine Diaphragm With and Without Ultrasound Therapy for Reconstruction of Abdominal Wall Defects in Rabbits. Trends in Biomaterials & Artificial Organs, 35(4), 376-386. Retrieved from

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