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In the present work, a series of hydroxyapatite (HA) samples with the incorporation of Mg and Si ions into hydroxyapatite structure was successfully carried out by hydrothermal method in the presence of surfactant to regulate the growth of nanoparticles. Plenty of studies have been focused on the effect of magnesium and silicon on the growth of the new apatite layer, but no methodical study has been focused, until now, to compare the effect of such ions on the dissolution/growth process of HA. The incorporation of silicate ions into the HA structure led to the increase in HA lattice parameters, while the incorporation of magnesium ions led to the reduction of lattice parameters and crystallite size of magnesium doped HA produced. All the samples had the morphology consisting of the nanoparticles nanorods. Dissolution of samples in simulated body uid showed that the incorporation of Mg and Si in HA structure resulted in a considerable increase in the in vitro dissolution of HA. The prepared samples promoted exceptional in vitro apatite growth over 14 days with a Ca/P ratio close to 1.67.


Hydroxyapatite; Silicate; Magnesium; Doping; Apatite; In vitro bioactivity.

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How to Cite
El Mabrouk, K., & Bricha, M. (2021). A Comparative Study of In Vitro Dissolution Process in Silicon and Magnesium-Substituted Hydroxyapatite Bioceramics. Trends in Biomaterials & Artificial Organs, 35(4), 359-369. Retrieved from